Report of a Case of Hepatic Epithelioid Hemangioendothelioma

Naser EbrahimiDaryani, Ali ZareMehrjardi, Arash SamadiGhooshchi, MohammadReza Keramati, Atouas NayerHabibi


Epithelioid hemangioendothelioma (EHE) is a rare neoplasm of vascular origin which arises preferentially in soft tissue and bone, and rarely in the liver. Its vascular nature is confirmed by positive staining for factor VIII-related antigen and other endothelial cell markers (CD31, CD34) in addition to the pathologic characteristics of well-developed basal lamina, pinocytotic vesicles, and, more specifically, Weibel-Palade bodies. Immunohistochemical identification of factor VIII-related antigen is helpful in differentiating metastatic carcinoma from primary epithelial liver tumors. To the best of our knowledge, no patient with EHE of liver has been reported yet from our region. Herein, we present a 56-year-old man who presented with one episode of severe epigastric pain and finally diagnosed as having EHE of liver.


Epithelioid hemangioendothelioma; Liver neoplasms; Liver transplantation

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