Effects of using Mitomycin-C in Treatment of Benign Esophageal Strictures

Abstract

Background: Using bouginage or balloon dilatation is the standard treatment for benign esophageal strictures.

AÙŽbout two-thirds need repeated dilatations. For preventing recurrent strictures, many medications such as mitomycin-C have been used. Mitomycin-C is a special antibiotic with anti-neoplastic characteristics, which inhibits fibroblast proliferation, reduces collagen production and decreases scar formation.

Materials and Methods: In this study, 12 patients with benign esophageal stricture during Azar 1386 to Bahman 1387 in Imam Khomeini Endoscopy Department were included.Ù Esophageal endoscopy was done and mitomycin-C was applied on the place of stricture using a cotton ball. Then, response to treatment was categorized in three groups of complete response, partial response and non-response to treatment.

Results: Average number of using mitomycin-C was 4 ± 3 times. Mean interval between endoscopies before using mitomycin-C was 3.5 ± 1 weeks and after using this agent was 8.5 ± 4.3 weeks. There were 4 cases of complete response, 5 cases of partial response and 3 patients of non-response.

Conclusion: Conservative treatments in management of benign esophageal strictures are preferred to more invasive treatments. However, it seems using a topical solution of mitomycin-C carries better responses and reduces the rate of recurrent dilatations.