Evaluation of Hairy and Enhancer of Split(HES-1) Expression in Different Types of Colorectal Polyps

Abstract

Background:

Colorectal cancer (CRC) is considered to be the fourth leading cause of cancer death worldwide.

Objectives: This study aimed to investigate the Hairy and Enhancer of Split-1 (HES-1) expression in different types of colorectal polyps.

Materials and Methods:

In this analytical study, we included 100 patients with colorectal polyps who were referred to Tehran, Iran. HES-1 immunostaining was performed to evaluate nuclear and/or cytoplasmic staining for HES-1 in the specimens. Then, the data were analyzed in terms of age, sex, side location, and polyp type.

Results:

 Out of 100 subjects, 62 were men and 38 were women. The highest prevalence of polyps was observed in the rectum (34%), and the most common type of polyp was tubular adenoma (40%). HES-1 index was only positive in 22 cases. There was a significant relationship between HES-1 positivity and both polyp location (P<0.001), polyp type (P<0.001), and grade of dysplasia (P=0.019). However, there was no significant relationship between HES-1 positivity and adenomatous polyp type (P=0.52). The distribution of HES-1 positivity on the left side was significantly higher, and the relationship between HES-1 positivity and side location was significant (P=0.002).

Conclusion:

This study suggests that HES-1 can be useful in differentiating SSA/P and HP with high sensitivity and specificity.