Evaluation of relation between air pollution and IBD flare

Pezhman Alavinejad, Seyed ali Mard, Sadegh Larki, Abdolrahim Masjedizadeh, Eskandar Hajiani, Seyed Jalal Hashemi, Farzad Jassemi Zergani, Elham Karimi Moghaddam


Background: To evaluate relation between air pollution and rate of flare and   hospital admission among IBD patients.

Methods: During a 10 months period, the number and average duration of hospitalization of patients admitted in GI ward due to IBD flare were recorded in an industrial capital city. Concomitantly the level of 4 major air pollutants including SO2, CO, NO2 and O3 measured and the correlation between severity of IBD flare and air pollution determined by Pearson correlation coefficient.

Results: Average number of admission was 7 patients per month (1-12). This figure for Crohn's disease (CD) was 2.9 and 3.7 for ulcerative colitis (UC). The average duration of hospitalization for UC and CD were 2.8 days (1 – 13) and 2.9 days (1 – 22) respectively. After comparison of average concentration of 4 major air pollutants with rate of IBD flare, , there was a relation, although non-meaningful, between CO concentration and number and duration of admissions due to UC flare (P= 0.135 & 0.08, correlation coefficient 0.196 & 0.251 respectively). DATA analysis did not reveal any significant relation between SO2 and NO2 and the rate of admission due to IBD flare (P > 0.05) and Interestingly there were a reverse meaningful correlation between concentration of O3 and number and duration of admissions due to Crohn’s disease flare (P= 0.016 and 0.006, Correlation Coefficient -0.338 & -0.413 respectively).

Conclusion: It seems that CO as one of the major air pollutants can aggravates course of ulcerative colitis and on the other hand O3 could have a potential protective effect on Crohn’s disease. This issue should further be clarified in future studies.


CD, UC, flare, air pollution

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